Our vision is to provide a new and efficient bone regeneration system for rapid repair of extensive bone fractures for the millions of patients suffering from massive bone loss.
Rapid Bone Regeneration System
Pre-clinical data on file.
Pre-clinical data on file.
A biodegradable scaffold, which attracts and retains the patient's own stem cells, is placed in the fracture.
After two weeks, osteogenic (i.e., bone-forming) molecules and microbubbles are injected.
Ultrasound is applied to activate the stem cells to form new bone.
New bone is formed, the fracture is repaired and the patient regains function.
Based on more than 25 years of research.
$2.5 billion
market for bone grafts and substitutes 2
8.5%
growth rate per year 3
1.5 million bone grafting procedures performed each year using allografts, autografts or substitutes
Allograft |
Autograft |
Bone Substitutes |
SonoHeal |
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| Bone graft obtained from a donor | Bone graft obtained from one site of the patient's body to be used in another site | Graft made from synthetic or naturally occurring substrate | Biodegradable scaffold, osteogenic molecule and ultrasound activate patient's stem cells to form new bone | |
Osteogenic |
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Osteoconductive |
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Osteoinductive |
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Low immune reaction |
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Low infection risk |
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High availability |
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Low morbidity Additional bone removal procedure |
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Dan Gazit, PhD, DMD
After receiving a B.Sc. in Biomedical Sciences, a Doctorate in Dental Medicine and a Ph.D. in Bone Biology from the Hebrew University of Jerusalem, Israel, Dr. Gazit carried out postdoctoral research at the University of California, San Francisco. Since 1992 he has been the head of the Skeletal Biotech Laboratory at the Hebrew University. Since 2006 he has been the Director of the Skeletal Program at the Board of Governors Regenerative Medicine Institute, Department of Orthopedics and Department of Surgery at Cedars-Sinai Medical Center in California. Currently, Dr. Gazit is a Professor at Cedars-Sinai Medical Center and the Hebrew University of Jerusalem.
author of 150+ peer-reviewed papers
inventor on 13 patents and patent applications
Zulma Gazit, PhD
After receiving an M.Sc. in Clinical Biochemistry from the University of Buenos Aires and a Ph.D. in Immunology from the Hebrew University of Jerusalem, Israel, Dr. Gazit carried out postdoctoral research at the Cancer Research Institute in the University of California, San Francisco. Since 2000 she has been a research scientist focused on the study of mesenchymal stem cells at the Hebrew University. Since 2006 Dr. Gazit has been the co-Director of the Skeletal Program at the Board of Governors Regenerative Medicine Institute, Department of Orthopedics and Department of Surgery at Cedars-Sinai Medical Center in California. Currently, she is an Associate Professor at Cedars-Sinai Medical Center and the Hebrew University of Jerusalem.
author of 53 peer-reviewed papersinventor on 9 patents and patent applications
Gadi Pelled, PhD, DMD
Dr. Gadi Pelled received a B.Sc. in Biomedical Sciences and a Doctorate in Dental Medicine from the Hebrew University of Jerusalem, Israel. After specializing in gerodontology and oral pathology, he obtained a Ph.D. in Tissue Engineering from the Hebrew University. Since 2006 he has been a research scientist at the Hebrew University and an Assistant Director of the Skeletal Program at the Department of Surgery at the Board of Governors Regenerative Medicine Institute and Department of Surgery at Cedars-Sinai Medical Center in California. Currently, Dr. Pelled is an Assistant Professor at Cedars-Sinai Medical Center and the Hebrew University of Jerusalem.
author of 60 peer-reviewed papersinventor on 11 patents and patent applications
Andrew Bryans
Andrew Bryans brings 25 years of experience in the healthcare industry and over 15 years serving executive type roles for early to mid-stage start-up companies with disruptive technologies. He has vast knowledge in orthopedic/spine medical devices seeking to enhance the quality in patient care and a broad understanding of the provider network.
commercialized 28+ products newly approved by the FDAParticipated in 3 company mergers / acquisitions
Eric Ley, MD
Dr. Ley is the Director of Surgical Intensive Care Units and Director of Surgical Critical Care Residency Program in the Department of Surgery at Cedars-Sinai Medical Center. He earned a B.A. degree from the University of California, Berkeley and an M.D. from Ohio State University. Dr. Ley completed an internship and residency, serving as Chief Resident, in general surgery at the University of Southern California followed by a fellowship in trauma and critical care at Cedars-Sinai. Dr. Ley is board certified in surgery and surgical critical care, specializing in trauma services.
author of 120 peer-reviewed papersinventor on 3 patents
Katherine W. Ferrara, PhD
Dr. Ferrara is a Distinguished Professor of Biomedical Engineering at University of California-Davis (UC Davis) and the Director of the Center for Content Rich Evaluation of Therapeutic Efficacy. Dr. Ferrara received her Ph.D. in Electrical Engineering from UC Davis. Following an appointment as an Associate Professor in the Department of Biomedical Engineering at the University of Virginia, Charlottesville, Dr. Ferrara served as the founding chair of the Department of Biomedical Engineering at UC Davis.
author of 300+ peer-reviewed papersinventor on 5 patents and patent applications
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